Information provided by (Responsible Party): dr. Laura C. G. de Graaff-Herder, Erasmus Medical Center. The This site is protected by reCAPTCHA and the Google A preliminary analysis of the phenomenology of skin-picking in Prader-Willi syndrome. What causes Prader-Willi syndrome Driscoll DJ, Miller JL, Schwartz S, Cassidy SB. Scoliosis can be present at birth or can develop during adolescence. Adult Prader-Willi Syndrome: An Update on Management They get tired easily and can fall asleep during the day. Member organisations are the Parenting Research Centre and the Murdoch Childrens Research Institute with The Royal Childrens Hospital Centre for Community Child Health. We pay our respects to the Traditional Owners and to Elders both past and This study aimed to characterize the perinatal features of 134 Chinese individuals with PWS. Where Can I Find Clinical Care Recommendations and Practice Guidelines? Changes in the following laboratory measurements: Choosing to participate in a study is an important personal decision. Adults with PWS are also more at risk of developing serious health problems linked with obesity, such as diabetes and heart disease. This happens by chance. Please select the most appropriate category to facilitate processing of your request. Prader-Willi syndrome To measure the effect of GHt on physical and psychosocial health in adults with PWS. The upper back normally curves forward somewhat. WebIn this case, when the paternal contribution is lost, the result is a condition known as Prader-Willi syndrome (PWS). Commenting on the research, Marguerite Hughes from the International Prader-Willi Organisation said, "This study is a welcome addition to the growing volume of research highlighting the impact of Prader-Willi syndrome on quality of life and the need for support, not alone to children with the syndrome, but also their parents and entire families. Perinatal features of Prader-Willi syndrome: a Chinese It stems from a problem with one of your chromosomes (a strand of DNA that Bookshelf and transmitted securely. If you have other children, they might have a range of feelings about having a sibling with disability. What Is the Life Expectancy of PWS strong preoccupation with food, which makes it hard for children to concentrate on other things, unusual behaviour related to food for example, hoarding food, high sensitivity to stress, which makes it hard for children to cope with things like changes to routine, difficulty telling the difference between real things and made-up things, undetected infections or injuries because of their high pain tolerance, a higher risk of choking because of their inability to vomit, tasks that involve visual-spatial skills, like solving jigsaw puzzles, decoding letter patterns and word recognition. -. An unrelenting feeling of hunger is common. Accessibility Prader-Willi syndrome (PWS) is Prader-Willi syndrome - Diagnosis and treatment - Mayo Clinic 4 Early diagnosis is best because it enables 2018 Sep;55(9):594-598. doi: 10.1136/jmedgenet-2017-105118. Unauthorized use of these marks is strictly prohibited. This part of the chromosome is called unstable because it is prone to being shuffled around by the cell's genetic machinery before the chromosome is passed on from parent to child. sharing sensitive information, make sure youre on a federal a complex neurodevelopmental disease that is caused by absence of paternal expressed imprinting genes at chromosome 15q1113 region. Prader-Willi Syndrome: Symptoms, Causes, and Treatments Minor Clinical Criteria of Prader-Willi Syndrome Decreased movement and noticeable fatigue during infancy Behavioral problems-specifically, temper tantrums, obsessive-compulsive behavior, stubbornness, rigidity, stealing, and lying (especially related to food) Sleep problems, including daytime sleepiness and sleep disruption Retrieved June 13, 2012, from, US Department of Health and Human Services, Women in Science Profiles: Text Alternative, Bioinformatics and Scientific Programming Core, Christina Tatsi Lab: Unit on Hypothalamic and Pituitary Disorders, Philip Adams Lab: Group on Gene Regulation in Bacterial Pathogens, Sarah Sheppard: Unit on Vascular Malformations, National Center for Medical Rehabilitation Research (NCMRR), Best Pharmaceuticals for Children Act (BPCA), Care for Babies with Congenital Zika Syndrome, Fragile X-Associated Primary Ovarian Insufficiency (FXPOI), Fragile X-Associated Tremor and Ataxia Syndrome (FXTAS), Intellectual and Developmental Disabilities (IDDs), National Child and Maternal Health Education Program, Active Funding Opportunity Announcements (FOAs) and NIH Guide Notices (NOTs) for NICHD, Parent Announcements (For Unsolicited or Investigator-Initiated Applications), SEEKER The First FDA-Authorized Newborn Screening Platform for Lysosomal Storage Disorders, Simbex Head Impact Telemetry System Real-time Monitoring to Improve Safety in Sports, SpermCheck FDA-Cleared Home Test for Male Fertility, bili-hut FDA-Cleared Phototherapy for Treating Newborn Jaundice at Home, Elagolix The First FDA-Approved Treatment for Endometriosis and Uterine Fibroids, BuzzyPain Relief for Pediatric Vaccinations, Miya Model Surgical Training Simulator for Obstetrician-Gynecologists (OB/GYNs), Support for Training at Universities and Other Institutions, Training in the Division of Intramural Research (DIR), Training in the Division of Population Health Research (DiPHR). Talking to other parents can be a great way to get support too. Then, between the ages of 1 and 6, appetite increases, often becoming insatiable. Prader-Willi syndrome is a genetic disorder that causes poor muscular tone (severe hypotonia), feeding problems, and delayed growth in infants. This study included the patients of a PWS registry in China. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). speech and language delays and difficulties. Copyright 2023 Merck & Co., Inc., Rahway, NJ, USA and its affiliates. Prader-Willi Syndrome (PWS) - Eunice Kennedy Shriver National -. Bethesda, MD 20894, Web Policies We do not control or have responsibility for the content of any third-party site. Other physical signs and symptoms can include: Cognitive signs Most children with Prader-Willi syndrome have mild to moderate intellectual disability. Further studies are needed for elucidating the mechanism of PWS. Read more on Dietitians Australia website. Prader-Willi syndrome is a rare genetic disorder that affects development and growth. Abnormalities of the face include almond-shaped eyes and a mouth with thin upper lips and down-turned corners. The diagnosis can be confirmed by chromosomal testing. Specialized therapy can help your child deal with sleep apnea, thyroid issues, and other symptoms common to this condition. But if you plan to have a baby, you and your partner can be screened for PWS risk. Skin picking is highly prevalent in people with Prader-Willi syndrome (PWS). Higher mean maternal age was found in this cohort (30.5 vs. 26.7), particularly in the maternal uniparental disomy (UPD) group (36.0 vs. 26.7) comparing with the general population. Perinatal and neonatal presentations were analyzed, and compared between the two PWS genetic subtypes. Importantly it will also enable families to continue to provide care within the home environment.". Federal government websites often end in .gov or .mil. We pay respect to Elders past, present and emerging. Although anti-obesity medications (AOMs) are prescribed to this population, there are no consensus guidelines on acceptability, safety, and efficacy. Please enter manually below. Some people are not accurately diagnosed until they are in their 20s or 30s. Combined with an insatiable appetite, this can lead to life-threatening obesity. The hands and feet remain small, and children remain short. The content is provided for information purposes only. To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. clinical governance framework. MeSH The study was carried out alongside a research team from Children's Health Ireland (CHI) at Tallaght University Hospital. Journal of the American Academy of Child & Adolescent Psychiatry, 32(4), 870873. Prader-Willi Syndrome is a complex genetic condition which causes neurological, hormonal, behavioural, developmental, and cognitive problems. 2005 Jul 25;7(14):1-20. doi: 10.1017/S1462399405009531. It can lead to excessive eating and life-threatening obesity, as well as obsessive/compulsive behaviours. They may have almond-shaped eyes, their head may get narrow at the temples, theirmouth might turn down at the corners, and they might have a thin upper lip. Related information on Australian websites, Prader-Willi Syndrome Association of Australia, development and quality assurance of healthdirect content, floppiness, difficulty sucking to feed, and, distinctive facial features (including a narrow bridge of the nose, a high and narrow forehead, a thin upper lip and downturned mouth, almond-shaped eyes, and eyes that look in different directions), undescended testes and small genitalia in boys, light skin and hair compared with other people in the family. Disclaimer. There's no cure, but if you have a child with PWS, you can help them stay at a healthy weight, have a good quality of life, and prevent health problems down the road. 2005 - 2023 WebMD LLC. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Brought to you by Merck & Co, Inc., Rahway, NJ, USA (known as MSD outside the US and Canada)dedicated to using leading-edge science to save and improve lives around the world. Higher maternal age may be a risk factor of PWS, especially for UPD. If you need support, you could start by talking with your GP or a genetic counsellor. Neurosci Biobehav Rev. The primary objective is to measure the effect of GHt on lean body mass as measured by Dual Energy X-ray Absorptiometry scan in adults of 30 years or older This change happens by chance and isnt inherited. Prader-Willi syndrome (PWS) is a rare genetic condition that results in a variety of symptoms. Only data that are collected as part of regular patient care will be used. Also the occurrence of side-effects will be assessed. Background: Prader-Willi syndrome (PWS) is a rare and complex genetic disorder caused by lacking expression of imprinted genes on the paternally Before The overall objective is to measure the effect of growth hormone treatment (GHt) on physical and psychosocial health in adults of 30 years or older with Prader-Willi syndrome (PWS). Findings also showed parents perceived increased weight and age of their child to have a significant negative impact on their child's psychosocial health and social functioning. For general feedback, use the public comments section below (please adhere to guidelines). About 70% of people who have Prader-Willi syndrome are missing part of chromosome 15. Prader-Willi Syndrome is a complex genetic condition which causes neurological, hormonal, behavioural, developmental, and cognitive problems. Methods: These trusted information partners have more on this topic. We currently support Microsoft Edge, Chrome, Firefox and Safari. https://www.pwcf.org/wp-content/uploads/2015/10/Genetic-of-PWS-Explanation-for-rest-of-us-20041.pdf, https://pubmed.ncbi.nlm.nih.gov/29271568/, Spotlight: Food for Health: Nutrition Research across the Lifespan, Experimental therapy for Prader-Willi syndrome shows promise in mice, National Child & Maternal Health Education Program. The primary endpoint is change in lean body mass (LBM (kg)) as assessed by Dual Energy X-ray Absorptiometry (DEXA) scan. Children rapidly gain weight. The information you enter will appear in your e-mail message and is not retained by Medical Xpress in any form. However, because of their uncontrollable appetite and other issues, adults with PWS are often not able to live independently. Driscoll DJ, Miller JL, Schwartz S, Cassidy SB. Grootjen LN, Uyl NEM, van Beijsterveldt IALP, Damen L, Kerkhof GF, Hokken-Koelega ACS. Your email is invalid. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. Poor muscle tone or limbs that hang loosely when you hold them, Inability to suck or nurse well, so they gainweight slowly, Have extra body fat and not enough muscle mass, Be slow to learn to talk, sit, stand, or walk, Lighter skin and hair color than the rest of the family, Inability to keep body temperature under control during a, Osteoporosis, or thin, weak bones that break easily. Experimental functional analysis of severe skin-picking behavior in Prader-Willi syndrome. They have feeding difficulties because their low muscle tone makes it hard for them to suck. For teens with PWS, hormones like testosterone, estrogen, or human growth hormone (HGH) may help with small stature, poor muscle tone, or extra body fat. 32.1% of neonates had birth asphyxia, 98.5% had hypotonia and 97.8% had weak cry or even no cry at neonatal period. Participants start with 0.2 mg/day and the dose increases with 0.2 mg/day per month to a maximum dose of 0.6-0.8 mg/day. working in partnership with your childs professionals, National Disability Insurance Scheme (NDIS), facial features like a narrow bridge of the nose, a high and narrow forehead, a thin upper lip and downturned mouth, almond-shaped eyes and a, problems regulating body temperature, which means children might not get fevers when they have infections, lighter skin, eyes and hair compared with other family members, difficulty with maths, reading and writing, difficulty recognising and interpreting sounds, difficulty with organising information, problem-solving and planning. Symptoms may include alterations to the persons speech, mobility, memory and even personality. Early intervention includes therapies, education and other supports that will help your child reach their full potential. Health professionals diagnose Prader-Willi syndrome by looking at the physical and other signs listed above. This study included 134 patients with PWS (115 patients with 15q11-q13 deletion and 19 with maternal uniparental disomy). 2016 Jun;41(4):261-71. doi: 10.1503/jpn.140338. For general inquiries, please use our contact form. WebPrader-Willi syndrome (PWS) is a rare genetic condition that affects your childs metabolism and causes changes to their body and behavior. Individual Participant Data (IPD) Sharing Statement: The individual participant data has not been finalized yet. Some kids even eat food that's still frozen or in the garbage. healthdirect's information and advice are developed and managed within a rigorous Epub 2015 Jun 24. These signs of PWS are less common, but some people have them: Because their sex organs don't develop, women with PWS may never get a period. Cassidy, S. B., & Schwartz, S. (2009). Prader-Willi syndrome is a genetic disorder that causes poor muscular tone (severe hypotonia), feeding problems, and delayed growth in infants. It affects all Complication; Feature, perinatal; Prader-Willi syndrome. Obsessive-Compulsive Disorder (OCD) and Related Disorders in Children and Adolescents. Sachin Vyas, 38, was last seen in Rufford Colliery Lane at 12.40pm today (Tuesday, August 4). WebPrader-Willi Syndrome. DOI: 10.1111/apa.15738. You can unsubscribe at any time and we'll never share your details to third parties. Pre-Application Process for NICHD Network Multisite Clinical Research, NICHD Policies for Data & Safety Monitoring, Clinician-Scientist Investigator (CSI) Curriculum, Office of Administrative Management (OAM), Office of Data Science and Sharing (ODSS), Office of Legislation, Public Policy, and Ethics (OLPPE), Office of Science Policy, Reporting, and Program Analysis (OSPRA), Division of Population Health Research (DiPHR), NCMRR Funding Opportunity Announcements (FOAs), Snapshot of Pregnancy & Infant Development Advances, Snapshot of Adult & Family Health Advances, National Advisory Child Health and Human Development (NACHHD) Council, National Advisory Board on Medical Rehabilitation Research (NABMRR), Task Force on Research Specific to Pregnant Women and Lactating Women (PRGLAC). Prader-Willi syndrome is caused by genetic changes on an "unstable" region of chromosome 15 that affects the regulation of gene expression, or how genes turn on and off. Listing a study does not mean it has been evaluated by the U.S. Federal Government. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). It affects a part of their brain called the hypothalamus -- this is what tells you you're full when you eat enough food. Raising Children Network is supported by the Australian Government. The genetic changes that cause Prader-Willi syndrome occur in a portion of the chromosome, referred to as the Prader-Willi critical region (PWCR), around the time of conception or during early fetal development.1 This region was identified in 1990 using genetic DNA probes. In affected children 3 years of age and older, other symptoms become apparent, such as obesity, intellectual delays, learning disabilities, or behavior problems, especially connected with food and eating.3. The https:// ensures that you are connecting to the Goldstone AP, Holland AJ, Hauffa BP, Hokken-Koelega AC. Gold JA, Mahmoud R, Cassidy SB, Kimonis V. Am J Med Genet A. doi: 10.1038/gim.0b013e31822bead0. Click here to sign in with How do healthcare providers diagnose PWS? Change in lean body mass (in kg) as measured by Dual Energy X-ray Absorptiometry scan, Change in fat mass (in kg) as measured by Dual Energy X-ray Absorptiometry scan, Change in bone density (in T-score) as measured by Dual Energy X-ray Absorptiometry scan, Change in physical strenght as measured by handgrip dynamometer and sit-to-stand tests, Change in psychosocial functioning as estimated with the Adult Behaviour Checklist, Change in caregiver burden as estimated with the Zarit Burden Interview, Change in weight (in kg) and waist-hip ratio. Orphanet J Rare Dis. MeSH Talk with your doctor and family members or friends about deciding to join a study. Data collection throughout routine clinical care with subcutaneous injections Genotropin, 0.6-0.8 mg/day. 1 This region was identified in 1990 using genetic DNA probes. J Clin Med. Careers. Kids with PWS should get regular eye exams to check for vision problems. Professor of Paediatrics at Trinity College, Edna Roche said, "We found that Prader-Willi syndrome impacts significantly on quality of life in both the affected child and the family. to the content webpage. What are the symptoms of Prader-Willi syndrome? By clicking Subscribe, I agree to the WebMD, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Bird Flu Deaths Prompt U.S. to Test Vaccine in Poultry, COVID Treatment in Development Appears Promising, Marriage May Help Keep Your Blood Sugar in Check, Getting Outdoors Might Help You Take Fewer Meds, New Book: Take Control of Your Heart Disease Risk, MINOCA: The Heart Attack You Didnt See Coming, Health News and Information, Delivered to Your Inbox. Prader Neurodevelopmental disorder; PraderWilli syndrome; Self-injurious behaviour; Skin picking. Genetic counseling helps people understand their risks. Banga, A., & Connor, D. F. (2012). People who have PWS usually aren't able to have children. Conclusions: Secondary endpoints are total fat mass, bone density, physical health and psychosocial health. In many cases of Prader-Willi syndrome, diagnosis is prompted by physical symptoms in the newborn. According to the Prader-Willi Syndrome Association in the United States, between 1 in 8,000 and 1 in 25,000 people live with the condition. Epub 2014 Jun 19. Medical concerns linked with Prader-Willi syndrome Children with Prader-Willi syndrome can have medical concerns like: Strengths Children with Prader-Willi syndrome often have strengths in: Children with Prader-Willi syndrome also tend to be caring and personable, with a good sense of humour. Results showed that parents of teenage children with Prader-Willi syndrome reported an increased burden of care made worse by psychological difficulties, and when the child's routine or social activities were disrupted and restricted. Use for phrases Almost all individuals with Prader-Willi syndrome have an abnormality within a specific area of chromosome 15.4 Early diagnosis is best because it enables affected individuals to begin early intervention/special needs programs and treatment specifically for Prader-Willi symptoms. Depression causes and treatment. In: Adam MP, Ardinger HH, Pagon RA, Wallace SE, bean LJH, Stephens K, Amemiya a, editors. American Psychiatric Association. (Eds.). Children with PWS are usually able to go to school and may go on to work in supported employment. 2022 Jun 13;17(1):221. doi: 10.1186/s13023-022-02302-z. Prader-Willi syndrome: MedlinePlus Genetics Listing a study does not mean it has been evaluated by the U.S. Federal Government. If your child tries to grab and hide food, you might lock cabinets, the pantry, or the refrigerator. of RAD011 (Cannabidiol Oral Solution) for The complex needs of children with Prader-Willi syndrome also suggest that social care services must be tailored specifically to the needs of people with the syndrome to be effective. Prader-Willi (PRAH-dur VIL-e) syndrome is a rare genetic disorder that results in a number of physical, mental and behavioral problems. type of skin picked, apparent motivations, or management strategies) of skin picking to inform intervention strategies. Epub 2018 May 18. Eventually these symptoms resolve. Akefeldt, A., & Gillberg, C. (1999). To locate a genetics or prenatal diagnosis clinic, see the GeneTests Clinic Directory. Professor Roche explained, "Provision of appropriate respite care for children and young people with Prader-Willi Syndrome along with increased support for their families will not only enhance the healthcare outcomes of affected patients, it will improve their quality of life and that of their families. Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT04484051. Background: This syndrome is a rare condition, which happens in 1 in 15 000 births. This study aimed to characterize the perinatal features of 134 Chinese individuals with PWS. Keywords provided by dr. Laura C. G. de Graaff-Herder, Erasmus Medical Center: Why Should I Register and Submit Results? PWS Information - IPWSO This number accounts read more . A head or brain injury can also cause the syndrome. Call 1800 022 222. A message has been sent to your recipient's email address with a link The overall objective of this study is to measure the effect of growth hormone (GH) treatment on physical and psychosocial health in adults with Prader-Willi syndrome. (See also Overview of Chromosome Disorders .) This site needs JavaScript to work properly. Behaviour signs One of the key characteristics of Prader-Willi syndrome is excessive appetite. People with PWS don't get the feeling of being full, so the most common signs are nonstop hunger and weight gain. All rights reserved. Newborns with the defect feel limp, feed poorly, and gain weight slowly. HHS Vulnerability Disclosure, Help National Library of Medicine The changing purpose of Prader-Willi syndrome clinical diagnostic criteria and proposed revised criteria. Prader-Willi syndrome (PWS) is a rare, complicated condition that affects many parts of your body. In Pagon, R. A., Bird, T. D., Dolan, C. R., Stephens, K., Adam, M. P. If a newborn is unable to suck or feed for a few days and has a "floppy" body and weak muscle tone, a health care provider may conduct genetic testing for Prader-Willi syndrome.1,2,3 Formal diagnostic criteria for recognizing Prader-Willi syndrome depend on the age of the individual-specifically, whether the third birthday has been reached. Would you like email updates of new search results? The data will become available around begin 2027 (after publication of the results). Multicentre study of maternal and neonatal outcomes in individuals with Prader-Willi syndrome. Unable to find your location. (2010). ", More information: Prader-Willi syndrome. The .gov means its official. Free Australian health advice you can count on. Accessibility In: Adam MP, Everman DB, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. In the United States, about 160,000 people have bariatric surgery each year. Prader-Willi syndrome is caused by a genetic change on chromosome 15. People with PWS simply cannot control their appetite their brain doesnt tell them they have had enough to eat. The link you have selected will take you to a third-party website. Nineteen parents/carers who observe skin picking shown by the person they care for completed a semi-structured interview. They have severe low Perinatal features of Prader-Willi syndrome: a Chinese Diagnostic and statistical manual of mental disorders (5th ed.). or, by Trinity College Dublin. You have reached the maximum number of saved studies (100). At raisingchildren.net.au we acknowledge the traditional custodians of the land on which we live, gather and work. Many symptoms of Prader-Willi syndrome vary according to the child's age. It also gives you funding for things like early intervention therapies and assistive technologies. Before Unauthorized use of these marks is strictly prohibited. Support for this browser is being discontinued for this site. Before age 3, the most important symptom is extremely poor muscle tone, called hypotonia, which makes infants feel floppy. This shows if there's a problem with the gene that can cause PWS. 8600 Rockville Pike -, Bar C, Diene G, Molinas C, Bieth E, Casper C, Tauber M. Early diagnosis and care is achieved but should be improved in infants with Prader-Willi syndrome. Their treatment will depend on the symptoms. Genetic testing must confirm the Prader-Willi syndrome diagnosis. Read more on Garvan Institute of Medical Research website. WebPrader-Willi syndrome (PWS) is a genetic condition that affects many parts of the body. Early intervention can improve outcomes for children with Rett syndrome. The site is secure. Adults with PWS who have not been treated with GH during the past three years and who will start with GHt as part of regular patient care. WebMD does not provide medical advice, diagnosis or treatment. However, we do not guarantee individual replies due to the high volume of messages. Please enable it to take advantage of the complete set of features! 2012;14(1):1026. Genetic counseling and testing provide individuals and families with information about the nature, inheritance, and implications of genetic disorders so that they can make informed medical and personal decisions about having children. Only about 1 in 10,000 to 30,000 people in the world have PWS. Often these newborns need help from a feeding tube. The https:// ensures that you are connecting to the Skin Picking in People with Prader-Willi Syndrome - PubMed If your child has a confirmed diagnosis of Prader-Willi syndrome, your child can get support under the National Disability Insurance Scheme (NDIS). Federal government websites often end in .gov or .mil. Prader-Willi syndrome is a chromosomal deletion syndrome in which part of chromosome 15 is missing. A gene is a segment of deoxyribonucleic acid ( DNA) and contains the code for a specific protein that functions in one read more .). Morgan JR, Storch EA, Woods DW, Bodzin D, Lewin AB, Murphy TK. WebPrader-Willi syndrome (PWS) is a rare, complicated condition that affects many parts of your body. Prader-Willi syndrome - About the Disease - Genetic and They also use genetic testing. 82.8% of the patients were born by caesarean section. Read about Garvan's research and latest findings. They may have small sex organs, and their voices may not change in puberty. Science X Daily and the Weekly Email Newsletter are free features that allow you to receive your favorite sci-tech news updates in your email inbox, Waking 'sleeping genes' could help Prader-Willi syndrome, Survey-based study suggests abstinence reboot interventions result in increased mental problems, Artificially speeding up a mouse's heart rate found to increase anxiety symptoms, Study unveils mechanism regulating the transmission of a protein associated with the progression of Parkinson's disease, How gut bacteria can impact treatments for cancer, Human feces and urine contain a motherlode of health data: 'Smart toilets' detect daily fluctuations, serious disease.

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